Normal Brain Glucose Metabolism in Neonates

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Abstract 
Background: Early phase of the life are very dynamic and important for postnatal brain
development. Better understanding of the normal growth pattern is essential to identify the abnormal pathogenesis of different neurological disorders.Materials and Method: In the present case report brain glucose metabolic pattern of a one year neurologically normal infant was scanned using Positron emission tomography (PET) with [18F] fluoro-2-deoxy-D-glucose (FDG) with a 3 month of follow-up.Results: During the baseline scan, frontal cortex showed comparatively greater SUVs when compared to other cortical and subcortical regions. During the follow-up scan, an increase in SUVs were seen in all regions. When the brain FDG-PET was visually accessed during the baseline maximum FDG uptake was seen in bilateral middle frontal cortex and occipital cortex. During the follow-up scan frontal cortex, posterior cingulate cortex, basal ganglia and occipital cortex showed maximum FDG uptake, this was followed by thalamus, anterior cingulate cortex, parietal cortex and cerebellum. Medial temporal cortex showed the lowest FDG uptake among the other regions of the brain.Conclusion: The present case report shows a definite pattern of normal brain development
and variation of FDG uptake over different regions in the infant.Keywords: Neonates, Brain, SUVs, FDG-PET, brain development

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