Early developmental changes in the brain

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AbstractBrain undergoes most of the dynamic change in utero and the developmental changes continue over the first two postnatal years of life. Early phase of life is very crucial as neurodevelopmental disorder such as Autism, ADHD are likely to be noticeable during the first years of life. Better understanding of normal brain pattern is necessary for identifying abnormal developmental pattern. In the present case, a typical neurologically normal infant was scanned using 18F-FDG PET during its sixth and ninth months. At sixth month, infant showed maximum 18F-FDG uptake in subcortical structures including basal ganglia and thalamus. After three months follow-up from the baseline the infant showed increased 18F-FDG uptake globally. Basal ganglia, thalamus and visual cortices showed maximum 18F-FDG uptake compared to other regions of the brain, while medial temporal cortex and
cerebellum showed the minimum 18F-FDG uptake. The present case demonstrates the brain 18F-FDG uptake in an infant and showed a pattern of development over a period. Infant brain 18F-FDG uptake changes throughout childhood and was not restricted to early postnatal years. Moreover, the present case report helps in determining the pattern of abnormalities associated with basal ganglia and thalamus.Keywords: 18F-FDG PET, Infant, basal ganglia, thalamus, brain

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